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This book discusses the effect of T4 Bacteriophage against the resistance uropathogenic E. coli bacteria. The appearance of resistant pathogenic bacteria to most, if not all, currently available antimicrobial agents has become a serious problem in modern medicine, especially because of the accompanying increase in immunosuppressed patients. The concern that human being is returning to the "preantibiotics" era has become very real and the development of alternative anti infection patterns has become one of the highest priorities of modern medicine and biotechnology. Before to the discovery and widespread use of antibiotics, it was proposed that bacterial infections could be treated and/or prevented by the administration of phages. Although, the early clinical studies with bacteriophages were not widely pursued in the Western Europe and United States, bacteriophages were utilized in the former Soviet Union and Eastern Europe. "The results of clinical studies were extensively published in Russian, Georgian, and Polish journals, so were not easily available to the western scientific community"