Radioiodination: Theory, Practice, and Biomedical Applications

The radionuclides of iodine have the greatest versatility in labelling both hydrophilic and lipophilic compounds that are used in biology and medicine. The multiple techniques for iodination and the clinical use of iodinated products have made possible the present status of the development of diagnostic nuclear medicine. A considerable amount of information on this topic is scattered through the literature and the author has gathered this and presented it in an ordered and systematic fashion, covering the period to 1990. On the basis of his extensive experience in laboratories of nuclear physics, nuclear chemistry, and radiochemistry, Dewanjee has produced a masterly, and above all practical book, directed at the gamut of readers, from basic scientists to clinicians and from students to experienced investigators. Each chapter is carefully structured, beginning with definitions and progressing to more comprehensive presentations of the disciplines of chemistry, biochemistry, molecular biology, physiology and pharmacology. The book is divided into six parts: Introduction; Preparation of Tracers; Localization of Tracers; Organ Imaging and Tracer Applications; Purification of Substrate, Quality Control of Tracers and Radiation Damage During Storage. A final part presents material for additional reading, being a supplement to the references that are cited at the end of each chapter. A clear and comprehensive index rounds off the work.