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This book looks at why certain regions are successful in creating an innovative technology cluster (with chapters on Silicon Valley and the Italian Food districts) and why aspiring communities and districts seek to learn from those examples and create an internationally successful region or sector (with chapters on the Dutch Biopartner program to stimulate entrepreneurship in the life sciences, on high-tech Israel and on the Italian Slow Food Movement). In some cases internationally renowned universities and/or research laboratories inspire engineers and scientists to become entrepreneurs and take the lead in cluster development (e.g. in the chapters on Food Valley Wageningen, the Knowledge Pearl Leuven-Flanders and the Scandinavian Oresund cluster). In other cases indigenous flagship firms, collaborating with each other and outsourcing many activities to smaller companies, may act as a region s catalyst (e.g. in the chapters on Flanders Vegetable Valley, the Dutch horticultural industry and the Defence Diversification Agency in the UK). Chapters on North Carolina s Research Triangle Park and the recent initiative to stimulate innovativeness in East Netherlands show that also an active government can stimulate emerging clusters by making local resources and funds available (e.g. risk capital, high-quality infrastructure), attracting foreign firms to invest and building ties between the private sector, knowledge institutions and local authorities.