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Elimination of microorganisms from infected root canals is a complicated task. There is no solid evidence in the literature that mechanical instrumentation alone results in a bacteria-free root canal system. Considering the complex anatomy of root canal pulp space, this is not surprising. On the contrary, there is in vitro and clinical evidence that mechanical instrumentation leaves significant portions of the root canal walls untouched and complete elimination of bacteria from the root canal by cleaning the root canal by instrumentation alone is unlikely. Therefore, specific irrigation / disinfection procedures are necessary to remove tissue from the root canals and to kill microorganisms, respectively. Considering the mentioned points, the purpose of this book was to collect interesting update data regarding the most common intra-canal medicaments in endodontics and dental traumatology.