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Imaging PET Reporter Transgenes in Living Subjects
Englisch
253 b
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Non-invasive imaging of transgene expression should§soon play a critical role in gene and adoptive§cellular gene therapy clinical trials. Positron§emission tomography (PET) reporter genes (PRG)/probes§(PRP) are currently the most advanced technologies§available for imaging transgens in humans. PRGs can§be used to image the location, magnitude, and time§variation of the intensity of transgene expression§throughout the whole body of a patient. This can§eliminate the need for multiple biopsies, which are§potentially dangerous and yet do not provide a§complete picture of whole body transgene expression§at multiple time points. This dissertation provides§details of several studies on direct and indirect§imaging of therapeutic transgenes using multiple§PRG/PRP systems in mice. Furthermore, it includes the§details of the first study on the pharmacokinetics,§dosimetry, and safety of an imaging reporter probe in§humans. Finally, a complete background on alternate§methods of imaging transgene expression has been§provided, concluding with a discussion of potential§future applications of imaging in gene therapy.
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