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Directed Evolution of the Aspergillus niger Epoxide Hydrolase
Englisch
159 b
30 Tage für die Rückgabe der Ware
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21.38
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Darwinian Evolution of an enzyme?? You might §wonder, what s this??§Genetic Evolution of a biocatalyst, scientifically §known as "directed evolution", has emerged in last §decade thanks to great advances in molecular biology §as a very powerful tool to genetically "manipulate" §an enzyme, either to improve enzyme properties, to §switch the selectivity or to create a completely new §catalyst.§Epoxides are versatile building blocks for natural §product synthesis. Quoting Prof. Seebach: If §carbonyl compounds have been said to be virtually §the backbone of organic synthesis, the epoxides §correspond to at least one of the main muscles , §this emphasized the importance of these compounds. §Epoxide hydrolases are useful biocatalysts to obtain §optically enriched epoxides.§This work applied directed evolution as a strategy §to improve the enantioselectivity of an epoxide §hydrolase. Different selection and screening methods §were established... What about the final result? §Take a look, you will find out!
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